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Zinc is a highly investigated nutrient in the treatment of COVID-19. Along with other health benefits, Zn effectively modulates the body’s immune response against various pathological agents and environmental hazards. It boosts innate and adaptive immune systems by providing antimicrobial, anti-inflammatory, antioxidant, and antiviral properties [17]. Studies showed that Zn deficiency impairs immune cells’ activation, maturation, and production, including lymphocytes, T cells, natural killer cells, and macrophages [17-19]. Moreover, Zn deficient individuals are prone to inflammatory conditions, viral infections such as HIV, Hepatitis C, and respiratory diseases (pneumonia). Researchers believe that Zn supplementation might prevent the development of COVID-19 and disease or symptoms severity, such as lessening diarrhea and loss of smell and taste. Also, medical studies linked lower Zn levels with a high risk of death, delayed recovery, medical complications, and disease severity [23-25]. Further, proper supplementation of Zn showed positive outcomes in a study (involving COVID-19 patients) as it improved COVID-19 symptoms, including headache, cough, fever, fatigue, body aches, and shortness of breath [20-25]. 

  1. Leal, Fernando and Garcia, Alejandra and Abarca, Lorena del Carmen and Gonzalez, Dinnaru and Cruz, Georgina and Montell, Marco and Ibarra, Antonio, Effect of a Nutritional Support System to Increase Survival and Reduce Mortality in Patients with COVID-19 in Stage III and Comorbidities: A Blinded Randomized Controlled Clinical Trial.. Available at SSRN: https://ssrn.com/abstract=3949424 or http://dx.doi.org/10.2139/ssrn.3949424
  2. Muhammed Majeed, Kalyanam Nagabhushanam, Kalpesh Shah, Lakshmi Mundkur, “A Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of a Nutritional Supplement (ImmuActiveTM) for COVID-19 Patients”, Evidence-Based Complementary and Alternative Medicine, vol. 2021, Article ID 8447545, 9 pages, 2021. https://doi.org/10.1155/2021/8447545
  3. Francisco Arrieta, Victoria Martinez-Vaello, Nuria Bengoa, Lucía Jiménez-Mendiguchia, Marta Rosillo, Angélica de Pablo, Cristina Voguel, Hilario Martinez-Barros, Rosario Pintor, Amaya Belanger-Quintana, Raquel Mateo, Angel Candela, José I. Botella-Carretero, Serum zinc and copper in people with COVID-19 and zinc supplementation in parenteral nutrition, Nutrition, Volumes 91–92, 2021, 111467, ISSN 0899-9007, https://doi.org/10.1016/j.nut.2021.111467.
  4. te Velthuis AJW, van den Worm SHE, Sims AC, Baric RS, Snijder EJ, van Hemert MJ (2010) Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture. PLoS Pathog 6(11): e1001176. https://doi.org/10.1371/journal.ppat.1001176
  5. Eric Finzil; Treatment of SARS-CoV-2 with high dose oral zinc salts: A report on four patients by; CASE REPORT| VOLUME 99, P307-309, OCTOBER 01, 2020; DOI: https://doi.org/10.1016/j.ijid.2020.06.006
  6. Vogel-González M, Talló-Parra M, Herrera-Fernández V, Pérez-Vilaró G, Chillón M, Nogués X, Gómez-Zorrilla S, López-Montesinos I, Arnau-Barrés I, Sorli-Redó ML, Horcajada JP, García-Giralt N, Pascual J, Díez J, Vicente R, Güerri-Fernández R. Low Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection. Nutrients. 2021; 13(2):562. https://doi.org/10.3390/nu13020562

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